It takes a fearless, unflinching love and deep humility to accept the universe as it is. The most effective way he knew to accomplish that, the most powerful tool at his disposal, was the scientific method, which over time winnows out deception. It can’t give you absolute truth because science is a permanent revolution, always subject to revision, but it can give you successive approximations of reality.
You may define ‘serendipity’ as the art of profiting from unexpected occurrences. When you do things in that way you get unexpected results. Then you do something else and you get unexpected results in another line, and you do that on a third line and then all of a sudden you see that one of these lines has something to do with the other. Then you make a discovery that you never could have made by going on a direct road.